Unfortunately the internationally researched standards for large print books, are not just an enlarged form of normal typesetting. And there is a big difference in producing books for those who are substantially sight impaired, and books for those of us who may have a slight deterioration in sight within the normal ranges of variation with age.
A chapter in the current edition of Type & Layout (the book by Colin Wheildon republished by The Worsley Press) -- although this is a chapter in the additional material by Geoffrey Heard -- does describe how preparing a book for the non-fluent reader is different to preparing a book for a fluent reader who may have minor sight problems, or no problems at all.
Just one quick example: although Wheildon's research showed that for reasonably fluent readers, justified serif type is by far the most readable, that is not true for someone who is less fluent, either through education or sight.
The chapter also includes information on the alternative of "Clear Type", a standard developed by the Royal National Institute for the Blind, with standards which, while being acceptable to a wide range of those with site problems, is more acceptable to others. While tending towards sans faces it does accept fonts with a good serif definition such as Bookman.
I would therefore warn against producing a smaller version of a large type, or even "Clear Type" book as a normal edition.
If the text of a book is correctly tagged in its preparation it would be a very simple matter to run it through with alternative layout specifications. I'd estimate an hour or two in a program such as InDesign, maybe even less in an entirely tag based layout program such as TeX.
There will need to be an entire new round of research into legibility on ebook readers.


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